The expression and role of interleukin-33 in patients with adult measles

Abstract

Objective To study the correlation between serum IL-33 and the indicators of clinical biochemistry and inflammation in patients with adult measles. Methods A total of 64 adult measles patients were selected and divided into acute liver damage group (n=36) and no liver damage group (n=28) . At the same time, 20 healthy adults were selected as healthy controls. Venous blood samples were collected on the day of admission, the 7th day and 14th day after treatment. The IL-33 and main indicators of liver function and inflammation were analyzed. Results Before the treatment, the levels of IL-33 in acute liver damage group, no liver damage group and control group were (185.20±19.44) pg/mL, (168.70±18.14) pg/mL and (132.17±12.41) pg/mL, respectively. The differences among three groups had statistical significance (F=13.17, P 0.05) . Serum IL-33 levels in patients with liver damage showed positive correlation with levels of ALT, γ-glutamyltranspeptadase and IL-6 (r=0.338 2, 0.200 3 and 0.597 2, P all<0.01) . Conclusions The serum IL-33 level has high expression in the measles complicated with liver damage, and its dynamic change reflects the severity and prognosis of liver inflammation. Key words: Measles; Liver damage; Serum IL-33