Abstract
17538 Background: Advances in the biology of CLL have led to the identification of new prognostic markers,which may improve the accuracy of classic parameters in predicting the clinical course.For this purpose,we evaluated the prognostic value of 70-kD zata-associated protein (ZAP-70) and CD38 in B-chronic lymphocytic leukaemia(B-CLL) combined with clinical state, β2-MG and LDH. Methods: Mult-parameter flow cytometry were used to detect the expression of ZAP-70 and CD38 in 71 B-CLL patients. Results: ZAP-70 and CD38 were concordantly expressed in 70.4% of B-CLL. (P<0.05) There was significant difference between ZAP-70+ and β2-MG(P<0.05).But no significant difference between ZAP-70 and LDH(P>0.05).In a subgroup of 15 consecutive patients analysis of CD38 and ZAP-70 expression were repeated in 2 years follow-up.The expression of CD38 was changed in 7 patients and ZAP-70 was not changed over time. Conclusions: Early prognostic parameters defected disease specificity. Using FCM to detect the expression of ZAP-70 and CD38 could be performed in clinical laboratory. The expression of ZAP-70 could be a novel prognostic indicators in B-CLL because it was not changed in whole course of disease. CD38 expression was an independent prognostic indicator and it could predict time to disease progression, as judged by treatment requirement. No significant financial relationships to disclose.
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