The expression and clinical significance of nuclear receptor co-activator 5 in colorectal cancer

Abstract

Objective To investigate the expression of nuclear receptor co-activator 5(NCOA5)in colorectal cancer tissues, and its correlation with clinicopathologial features. Methods The expression levels of NCOA5 mRNA and protein in 74 cases of colorectal cancer tissues were separately detected by real-time fluorescent quantitative polymerase chain reaction(FQ-PCR)and Western blotting. Meanwhile, we statistically analyzed the relationship between its expression levels and clinical data. Results The positive expression rate of NCOA5 mRNA(74.3%)and protein(83.8%)in colorectal cancer tissues was significantly lower than in the adjacent tissues. The expression of NCOA5 mRNA and protein in colorectal cancer tissues was significantly correlated with liver metastasis and differentiation(P<0.05), but not with gender, age, tumor size, Dukes stage and lymph node metastasis of colorectal cancer. Conclusion The low expression of NCOA5 may promote the development and metastasis of colorectal cancer, and can be a therapeutic target in patients with colorectal cancer. Key words: Colorectal cancer; Nuclear receptor co-activator 5; Liver metastasis