Abstract
Objective To investigate the expression and clinical significance of IGF2 and its role in the development of bladder cancer. Methods The overall-survival time of patients with different expression level of IGF2 was analyzed by the cancer gene information database(The Cancer Genome Atlas, TCGA) .The expression level of IGF2 in 63 cases of bladder urothelial carcinoma and 17 cases of normal tissue were derected by the immunohistochemical staining.The relationship between IGF2 expression level and clinical factors was analyzed. Results The overall-survival time of patients with high-expression IGF2 was significantly lower than that of low-expression IGF2 patients(P=0.049). The expression level of IGF2 in bladder cancer tissues was significantly higher than that in the normal tissues (P<0.01). In the muscle invasive bladder cancer(T2-T4), the expression level of IGF2 was significantly higher than the non-muscle invasive bladder cancer(Ta-T1). Besides, the expression level of IGF2 in high-grade bladder cancer was also significantly higher than that of low-grade bladder cancer, there was statistically significant(P<0.05). Conclusions The expression level of IGF2 in bladder cancer is negatively related to the overall-survival time, and it's closely associated with the progression of bladder cancer, IGF2 may be an important protein molecule for the target therapy and prognosis of bladder cancer. Key words: Urinary Bladder Neoplasms; Insulin-Like Growth Factor II
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