The Exploitation and Simulation of a Microfluidic Device Research on the Response of Cell Fluid Shear Stress

Abstract

This paper provides an economical and high efficient kind of microfluidic chip device which can investigate cells' response under different magnitude of fluid shear stress (FSS) at the same time. The experimental results of a large number of test groups in the same environmental conditions are more persuasive for conclusion. Cells are simultaneously cultured in different width of micro channel, and we verified the cell's shear force with a COMSOL simulation. In the experiment, Human vascular endothelial cell which possess apparent FSS response is selected to verify the reliability of the device. The results of the experiment show that cell response to FSS has obvious morphological differences in different test group.