The Experience of Blood Purification in Sepsis by Coupled Plasma Filtration Adsorption in Thailand

Abstract

Sepsis is an inflammation syndrome which is caused by severe infection. This severe inflammation is characterized by vasodilatation, leukocyte accumulation and increased microvascular permeability. The pathophysiology of sepsis is believed to be due to the dysregulation of the inflammatory response. The human body generates and releases a massive uncontrolled amount of proinflammatory mediators into the blood stream which causes cellular and tissue injury. This injury leads to the development of multiple organ dysfunction syndromes (MODS), and causes life-threatening conditions.