Abstract
THE EXCRETION OF VOLATILE SELENIUM COMPOUNDS AFTER THE ADMINISTRATION OF SODIUM SELENITE TO WHITE RATS
Highlights
Since it is usually accepted that the chief volatile product is dimethyl selenide, substances which might be expected to furnish methyl groups in metabolism and to facilitate the excretion of selenium in volatile form were administered in some experiments t.o the animals which received injections of sodium selenite
It is evident that the excretion of volatile selenium compounds does not vary significantly and under our experimental conditions is not materially influenced by the ingestion of choline or methionine
When sodium selenite (2.5 to 3.5 mg. of selenium per kilo) was injected subcutaneously into adult white rats, from 17 to 52 per cent of the injected selenium was excreted within 8 hours as a volatile compound which was absorbed by concentrated sulfuric acid
Summary
LEWIS (From the Department of Biological Chemistry, Medical of Michigan, Ann Arbor) It is commonly stated [1] that after the administration of selenium or tellurium salts, volatile methyl compounds, dimethyl selenide or telluride, are excreted through the lungs. Since it is usually accepted that the chief volatile product is dimethyl selenide, substances which might be expected to furnish methyl groups in metabolism (e.g., choline and methionine) and to facilitate the excretion of selenium in volatile form were administered in some experiments t.o the animals which received injections of sodium selenite. On the preliminary days and on the day of the selenium injection, the rats received a small piece of bread which had been moistened with the desired amount of choline chloride solution This was readily consumed and the animals were fed the standard laboratory stock diet of whole wheat bread, milk, and lettuce. The tubes were stoppered and placed in the dark for 20 to 30 minutes.’ The colors were compared in a
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