Abstract
DEHYDROISOANDROSTERONE is recognized as a steroid excretion product related to adrenal function, and it is excreted in large amounts by persons suffering from adrenal tumor (1, 2, 3) but not by those suffering from adrenal hyperplasia. These facts suggest that a study of this excretion product after stimulation of the adrenal cortex with adrenocorticotropic hormone (ACTH) would yield further information on the activity of the normal adrenal cortex. The recent contribution of Landau and associates (4), using the Pettenkofer reaction, again calls attention to dehydroisoandrosterone as an important excretion product connected with normal adrenal cortical activity. The well recognized instability of dehydroisoandrosterone to the hydrolysis with strong acid at high temperature used by previous investigators, led to the use of milder hydrolytic procedures. As pointed out by Leiberman and Dobriner (5) mild acid hydrolysis appears to be sufficient to liberate the steroids conjugated as sulfate and certainly dehyd...
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