Abstract
3D domain swapping is increasingly implicated in amyloidosis but also has potential functional advantages in soluble proteins. Indeed, the structure of an NF-κB p50 mutant (Chirgadze et al. 2004Chirgadze D.Y. Demydchuk M. Becker M. Moran S. Paoli M. Structure. 2004; 12 (, this issue): 1489-1494Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar) demonstrates that 3D domain swapping can rescue function after a destabilizing mutation. This work has wider implications for the evolution of protein oligomers.
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