Abstract
Extracellular vesicles (EVs) are approximately 30- to 150-nM particles that are generated by cells and are thought to mediate the transfer of bioactive cargo.1 Substantial evidence suggests that an under-appreciated role of EVs is the mediation of intercellular signaling via microRNAs (miRNAs).1,2 However, the concept that miRNAs packaged into EVs mediate intercellular signaling has recently been called into question by Albanese and Chen et al.,3 who report that miRNAs do not seem to be packaged appreciably into EVs and, furthermore, when they are, they have little to no effect on recipient cells.
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