Abstract
BackgroundExploring metabolic evolution is a way to understand metabolic complexity. The substrate transport of mitochondrial carrier family (MCF) influences direct metabolic activities, making it possible to understand indirectly metabolic evolution from the evolution of substrate transport of MCF. However, the evolutionary study of substrate transport of MCF does not mean that all the concrete structures of mitochondrial carriers (MCs) must first be gained.ResultsHere we studied the alternation of MCF structure and potential correlated functions of MCF during metazoan evolution. The data analysis indicates that the types of substrates transported by MCF as a whole were maintained during metazoan evolution. However, the size of the substrates transported by members of MCs continuously diminished during the evolutionary process. We have found that the ratio of hydrophobic amino acids at specific helix-helix interfaces increases significantly during vertebrate evolution. Amino acid's spatial positioning and the calculating of packing values both indicate the increase in the number of hydrophobic amino acids would lead to a more "tight" structure of the TR domain, which is in agreement with the trend of diminishing size of substrates transported by MCs. In addition, there was a significant increase in the number of carriers of MCF during vertebrate evolution.ConclusionsWe propose that the more "tight" TR structure generated by the increase of the hydrophobic amino acids at specific helix-helix interfaces during vertebrate evolution enhances the substrate selectivity of MCF, reflecting the evolutionary trajectory of MCF during metazoan evolution.
Highlights
IntroductionThe substrate transport of mitochondrial carrier family (MCF) influences direct metabolic activities, making it possible to understand indirectly metabolic evolution from the evolution of substrate transport of MCF
Exploring metabolic evolution is a way to understand metabolic complexity
The strong purifying selection indicates that mitochondrial carrier family (MCF) maintains a relatively stable substrate transport and its evolution is characteristic of continuity during metazoan evolution
Summary
The substrate transport of mitochondrial carrier family (MCF) influences direct metabolic activities, making it possible to understand indirectly metabolic evolution from the evolution of substrate transport of MCF. Mitochondrial carriers (MCs), located at the inner membrane of mitochondria (IMM), are responsible for transporting a variety of metabolites between the cytosol and the mitochondria and influence the activities of the metabolic pathway direct [1,2]. It is not possible to obtain the concrete structures of all mitochondrial carrier family (MCF) members through crystallization [1,13], and uncovering the mechanism of substrate selectivity of MCF direct is impossible solely by linear superposition
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