Abstract
The evolution of treatment for early breast cancer: what's next?
Highlights
Cancer Research Campaign Department of Medical Oncology, University of Manchester, Christie Hospital and Holt Radium Institute, Wilmslow Road, Manchester, M20 4BX, UK
The effect of oestrogen on breast cancer risk was first shown over 100 years ago when researchers found that removing the ovaries of women with breast cancer improved their chances of survival
Other early breast cancer trials that have followed thousands of women over many years have confirmed the benefits of aromatase inhibitors (AIs) treatment, indicating that five years of treatment with tamoxifen alone may be sub-optimal for all patients other than those at the lowest risk of recurrence
Summary
Post-surgery, the evolution of adjuvant therapy has meant that we have an armoury of effective treatments to stop breast cancer returning, debate continues on how these treatments should be used for maximum benefit. The effect of oestrogen on breast cancer risk was first shown over 100 years ago when researchers found that removing the ovaries of women with breast cancer improved their chances of survival.
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