The evolution of the microbiological landscape and antibiotic sensitivity in ICD patients

Abstract

Purpose of work . Reducing antibiotic resistance by introducing the proposed complex of prevention and control of infection in ICU. Materials and research methods. The work includes an analysis of bacteriological studies of 1111 patients undergoing treatment at the ICU of the Ternopil University Hospital for the period from January to August 2015 (group I) and for the same period in 2018 (group II). The set of innovations included: measures to prevent the spread of antibiotic-resistant pathogens and the rational use of antibiotics. Results and discussion . The largest changes in antibiotic sensitivity were found for imipinem. The growth of the latter by 60% (p≤0.05) was revealed, which amounted to 100% sensitivity of clinical isolates of Ps. Aeruginosa to imipinem. The preservation of the multi-resistance of the clinical isolates of Klebsiella pneumoniae in patients of group I and II, and a decrease in the number of seeding by 39%, is of great prognostic value. Conclusions . The range of proposed measures included the distribution of patients into blocks depending on the risk of developing infectious complications, monitoring antibiotic prescribing, observance of sanitary and hygienic standards by ICD personnel, the use of sodium hypochlorite, and the number of pathogenic isolates and the level of antibiotic resistance to certain groups of antibacterial drugs.