The evolution of the immune reactivity in patients with coronary artery disease under the influence of complex treatment

Abstract

In most cases, the main cause of coronary heart disease is atherosclero sis of the coronary arteries. Inflammation has an important role in the development of atherosclerotic process causes feasibility study of inflammatory markers in patients with coronary heart disease.The objective: study of inflammatory markers in patients with unstable angina and study their changes during treatment with statins and alpha-lipoic acid.Patients and methods. The study involved 61 patients with unstable angina. Depending on the therapeutic management, patients divided into two groups, the first group received conventional treatment with rosuvastatin, and the second group took the conventional treatment including rosuvastatin in combination with alpha-lipoic acid. Serum of patients were tested for interleukin 1-β, interleukin-6 and C-reactive protein.Results. Before treatment, patients with unstable angina revealed a significant increase in levels of cytokines and CRP compared to controls. After treatment was found a significant decrease in levels of interleukin 1-β, interleukin-6 and C-reactive protein in the serum of patients of both groups. However, more substantial reduction in these parameters was found in patients who additionally received alpha-lipoic acid.Conclusions. In patients with unstable angina revealed a significant increase in serum levels of interleukin 1-β, interleukin-6, C-reactive protein. As a result of the treatment found a significant decrease in these parameters. Rosuvastatin combined with alpha-lipoic acid results in a more significant reduction in interleukin 1-β, interleukin-6, C-reactive protein.