Abstract
All organisms must transmit genetic information to offspring through cell division, and mitotic spindle participates in the process. Spindle dynamics through depolymerization or polymerization of microtubules generates the driving force required for chromosome movements in mitosis. To date, studies have shown that microtubule arrays control the directions of cell division and diverse microtubule-associated proteins regulate cell division. But a clear picture of how microtubules and microtubule-associated proteins modulate cell division remains unknown. Depletion of end-binding protein 1 by RNA-mediated inhibition shows that one of the microtubule-associated proteins, end-binding protein 1, plays a crucial role in mitotic spindle formation and promotes microtubule dynamics and is needed for the proper segregation of mitotic chromosomes during anaphase in Drosophila cells. Here, we review the properties of end-binding protein 1 and the roles of end-binding protein 1 in regulating microtubule behavior and in cell cycle.
Highlights
The microtubule cytoskeleton is essential for a variety of essential processes such as intracellular organization, intracellular transport, cell motility, and mitosis of eukaryotic cells
Microtubules are structurally polar and dynamic filaments that grow by addition of guanosine triphosphate (GTP)-loaded tubulin subunits to their end
End binding (EB) proteins are part of a highly conserved family which, in mammalians, comprises three members encoded from three different genes: End-Binding Protein 1 (EB1), EB2 (RP1), and EB3 (EB3F)
Summary
The microtubule cytoskeleton is essential for a variety of essential processes such as intracellular organization, intracellular transport, cell motility, and mitosis of eukaryotic cells. This is possible because of the intrinsic dy-. It is widely known that MT behavior is modulated by a number of MT-associated proteins (MAPs), which can influence dynamic instability parameters and impact on mitotic progression and fidelity. Many of these MAPs share the ability to recognize only the distal part of a polymerizing MT, known as the MT plus end. A clear picture of how EB1 regulate microtubule behavior to drive chromosome segregation has not still emerged
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