Abstract
Coronavirus (COVID-19) is suspected to originate from an animal host (zoonotic) followed by a human to human transmission, The purpose of the present study is to determine the genetic affinity of a phylogenetic tree and conformation of protein between human and bat. Through study of genetic sequencing, as shown in the tree design of strains and genetic variants, the main cause of COVID-19 is the Bat Coronavirus RaTG13 (SARS) virus in ID: MN996532.1 and ID: MG772933.1 (24-Jul-2013 and Feb-2017) shows that the evolution of the Corona virus from 2003, 2013 to 2020 which has become the most deadly peak in humans, the virus evolved from the bat effect on Humans. Protein analysis show 98 change of amino acid form RaTG13 (SARS) virus to COVID-19 Homo sapiens. Consequently, this study increased our understanding of the genetic variety of the COVID-19 carried by bats. So we conclude that a protein conformation drawing shows high identity compatibility between a bat and a human
Highlights
The first cases of SARS were identified in 2002 in China (Guangdong Province)
The result of the sequence analysis was analyzed by blast in the National Center Biotechnology Information (NCBI) online and BioEdit program [14] to detect polymorphism after alignment of product amplification in Corona virus, showed that 98 change of amino acid form RaTG13 (SARS) virus Rhinolophus affinis to COVID-19
The phylogenetic tree diagrammatic was done by molecular evolutionary genetics analysis (MEGA) software version 6.0
Summary
The first cases of SARS were identified in 2002 in China (Guangdong Province). While in 2003 an epidemic has spread across the world that affected more than three thousand people ensuing in more than a hundred deaths [1]. SARS-CoV is an element of the Corona viridae family of enveloped positive-Stranded RNA viruses which have a great host range. An ongoing outbreak of pneumonia related with a novel corona virus that called a severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) in the persons was report in china-Wuhan, Hubei province, China in December-2019 [3].
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