Abstract
Purpose To describe and correlate the degree of anterior segment inflammation with central retinal and choroidal thickness throughout the treatment period (in the course of follow-up) in the eyes affected with acute anterior uveitis in the patients with seronegative spondyloarthropathy (subgroup: ankylosing spondylitis). Methods Thirty eyes of 30 consecutive Caucasian patients with HLA-B27-associated acute anterior uveitis were included in this study. The flare, AC cell number, and central retinal/choroidal thickness were determined at each visit by optical coherence tomography and laser flare photometry. Treatment consisted of topical corticosteroids. Statistical analysis was performed by MathWorks Matlab software. Results In the follow-up period, central retinal thickness was increased in the first 9-10 days and then decreased until stabilization (after 5-6 weeks). The flare and AC cell number decreased rapidly at the beginning of the treatment, in the first 10 days, and thereafter, slower decrease could be observed until complete resolution of inflammation. Statistically significant, positive correlation was found between initial laser flare value and maximal central retinal thickness (r=0.881, p < 0.001). Positive correlation between flare and retinal thickening was observable throughout the treatment period. Central choroidal thickness was decreased also significantly during the follow-up (p < 0.001). Conclusions The retina and choroid may play a biomarker function in the anterior segment inflammation of the eye in the patients with seronegative spondyloarthropathy.
Highlights
Spondyloarthropathy (SpA) is a group of chronic inflammatory rheumatic diseases, which are characterized by common clinical symptoms and genetic similarities [1].Spondyloarthropathy is genetically linked (90% of cases), and the strongest contributing factor is the HLA B27 antigen [1, 2].Ocular inflammation is a common extra-articular manifestation of seronegative spondyloarthropathy
The patients with a history of psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease (AIBD), other systemic diseases, intermediate uveitis, posterior uveitis, intraocular surgery, macular disease, and amblyopic eyes were excluded from the study
The mean initial laser flare value is reduced by 50% after 12 days
Summary
Spondyloarthropathy (SpA) is a group of chronic inflammatory rheumatic diseases, which are characterized by common clinical symptoms and genetic similarities [1].Spondyloarthropathy is genetically linked (90% of cases), and the strongest contributing factor is the HLA B27 antigen [1, 2].Ocular inflammation is a common extra-articular manifestation of seronegative spondyloarthropathy. Spondyloarthropathy (SpA) is a group of chronic inflammatory rheumatic diseases, which are characterized by common clinical symptoms and genetic similarities [1]. Spondyloarthropathy is genetically linked (90% of cases), and the strongest contributing factor is the HLA B27 antigen [1, 2]. Ocular inflammation is a common extra-articular manifestation of seronegative spondyloarthropathy. Anterior uveitis is one of the most important features with a prevalence of 25–. 30% in the SpA patients [1, 2]. Five major subtypes of SpA are recognized on the basis of recently proposed classification criteria (European Spondyloarthropathy Study Group). One of the most common subtypes of SpA ankylosing spondylitis (AS) was studied intentionally
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