Abstract
The evolution and development of the antibody repertoire.
Highlights
500 million years ago (1), vertebrates developed the ability to generate a highly diverse repertoire of immunoglobulins (Igs)
The fetal repertoire develops without maternal influences and the precocial nature of multiple offspring provides investigators with the opportunity to study the influence of environmental and maternal factors on repertoire development
Clinical surveys have suggested that anti-apoptotic cell (AC) IgM NAbs may modulate disease activity in some patients with autoimmune disease
Summary
500 million years ago (1), vertebrates developed the ability to generate a highly diverse repertoire of immunoglobulins (Igs). We collected several exciting articles that highlight the diversity and similarity of antibody repertoires. This review is followed by a comparative study by Mroczek and colleagues (5) of the antibody repertoire expressed by immature, transitional, mature, memory IgD+, memory IgD−, and plasmacytes isolated from the blood of a single individual.
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