Abstract
The Evans–Tishchenko reaction provides a highly diastereoselective route towards the synthesis of 1,3-<i>anti</i> diol monoesters, and therefore has found prominent use in a number of synthetic applications. This review summarises recent applications of the Evans–Tishchenko reaction in natural product synthesis, and examines scope in terms of substrate range, functional group tolerance, and catalyst. 1 Introduction 2 Reaction Mechanism and Catalyst Scope 2.1 Reaction Mechanism 2.2 Samarium 2.3 Scandium 2.4 Zirconium 2.5 Other Metals 3 Substrate Scope 4 Application in Natural Product Synthesis 4.1 Protection/Asymmetric Induction 4.2 Functional Group Interconversion 4.3 Fragment Linkage and Ring Formation 5 Future Perspectives 6 Conclusion
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