Abstract
The study of the prevalence and intensity of dental caries in patients with hereditary blood diseases is one of the urgent problems of stomatology. About 5% of the world population has different variations in the alpha or beta chain molecule of hemoglobin. The mean values of the intensity of carious lesions of the teeth varied depending on the age of the patients. So, with increasing age, the difference in DMFT index also increased. Analysis of the components of the DMFT index showed a predominance of the percentage of carious teeth over the filled teeth in the first and second age groups of healthy patients and a significant predominance of untreated teeth in all three groups among patients with β-thalassemia major.
Highlights
The study of the prevalence and intensity of dental caries in patients with hereditary blood diseases is one of the urgent problems of stomatology. β-thalassemia is one of the most common hereditary blood diseases caused by a gene defect that is responsible for synthesizing the β-chain of “ adult ” hemoglobin
Along with severe anemia, patients with β-thalassemia major as a result of transfusions suffer from the effects of iron overload [2,3,4]
The high frequency and intensity of caries of milky teeth in children with thalassemia, apparently, is associated with a decrease in their immunoreactivity against the background of progressive oxidative stress, initiated by excessive iron content [8,9,10]. It should be said about hyposalivation and high viscosity of the oral fluid, which contribute to enhancing the cariesogenic situation in the oral cavity in patients with β-thalassemia major [11]
Summary
The study of the prevalence and intensity of dental caries in patients with hereditary blood diseases is one of the urgent problems of stomatology. β-thalassemia is one of the most common hereditary blood diseases caused by a gene defect that is responsible for synthesizing the β-chain of “ adult ” hemoglobin. The high frequency and intensity of caries of milky teeth in children with thalassemia, apparently, is associated with a decrease in their immunoreactivity against the background of progressive oxidative stress, initiated by excessive iron content [8,9,10]. It should be said about hyposalivation and high viscosity of the oral fluid, which contribute to enhancing the cariesogenic situation in the oral cavity in patients with β-thalassemia major [11]. The purpose of this work was to study the prevalence and intensity of dental caries in children of different age groups with β-thalassemia major
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