Abstract
Rheumatoid arthritis (RA) was a chronic inflammatory autoimmune disease for long-term that primarily affects small joints and leads to chronic inflammation in synovial. The aimed of the study to identify the relationships among some serological markers (antibodies to citrullinated protein/peptide antigens (ACPAs), anti-mutated citrullinated vimentin (anti-MCV), anti-carbamylated protein (Anti-Carp), anti- heterogeneous nuclear ribonucleoproteins (anti-hnRNP) and Glucose-6-phosphate isomerase (GPI)) and early diagnosis of RA. The study involved (60) Patients of newly diagnosis with RA that divided in to two subgroups (30 RF positive and 30 RF negative) groups and 30 subjects as healthy control group. The serological data from serum concentration of (ACPAs, Anti-MCV, Anti-Carp, Anti-hnRNP, G6PI) estimated by ELISA methods, RF estimated by latex agglutination kits. The results revealed that ACPAs, Anti-MCV, Anti-Carp, Anti-hnRNP, G6PI having a statistical significants at the mean±SD titer different between the two RF groups, a higher value among the refractory RA patients in comparison with the control group. Also effectively distinguishing RA patients groups for RF+ve and RF-ve with showed the sensitivity and specificity of, ACPAs (90.8% , 94.1%, and 88.2%, 86.6%); anti-MCV (66.7% , 33.0% and 70.0%, 70.2%); anti-CarP (76.7% , 90.0% and 93.3%, 78.5%); anti-hnRNP (74.9% , 61.9% and 71.4%, 70.9%) and GPI (77.3% , 76.7% and 84.4%, 80.1%) respectively. This study confirm the importance of measuring multiple serum biomarkers and their comÂbinations with high diagnostic value for RA and provide supÂport for the early diagnosis of RA.
Highlights
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affects small joints and leads to chronic inflammation in the synovial fluid, resulting in the destruction of small joints, deformity, and disability [1]
RA patients are typically classified into two sub-groups, designated as seropositive and seronegative, with seropositivity referring to the existence in serum of high concentrations of the autoantibodies rheumatoid factor (RF) and antibodies to citrullinated protein/peptide antigens (ACPAs) [4]
The aim of this study was to identify the relationships between early diagnosis of RA with some serological markers, namely the antibodies to citrullinated protein/peptide antigens (ACPAs), anti-mutated citrullinated vimentin, anti-carbamylated protein (AntiCarp), anti- heterogeneous nuclear ribonucleoproteins and Glucose-6-phosphate isomerase (GPI)
Summary
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affects small joints and leads to chronic inflammation in the synovial fluid, resulting in the destruction of small joints, deformity, and disability [1]. The seropositive RA patients demonstrate specific genetic and environmental risk factors and were observed to have a more severe course of disease [5, 6]. It was demonstrated that the anti-mutated citrullinated vimentin (anti-MCV) antibodies might represent a precious factor for RA diagnose in anti- CCP-negative patients. A recent study observed that the presence of anti-CarP antibodies was significantly associated with the development of RA in ACPA and RF-negative patients [11]. Glucose6-phosphate isomerase (GPI) could be a practical biomarker for the newly diagnosed clinical RA, their correlation with RA acute states. The aim of this study was to identify the relationships between early diagnosis of RA with some serological markers, namely the antibodies to citrullinated protein/peptide antigens (ACPAs), anti-mutated citrullinated vimentin (anti-MCV), anti-carbamylated protein (AntiCarp), anti- heterogeneous nuclear ribonucleoproteins (anti-hnRNP) and Glucose-6-phosphate isomerase (GPI)
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