Abstract
DLBS2411 is a bioactive fraction from Cinnamomum burmannii that is believed to possess anti-ulceration activity. In this study acetic acid was administered to induce gastric ulcer. Rats were divided into six groups: Healthy animals, untreated animals (acetic acid-induced), treatment group of BAF DLBS2411 25 mg kg-1 Body Weight (BW), BAF DLBS2411 50 mg kg-1 BW and positive control group of omeprazole 2 mg kg-1 and sucralfate 100 mg kg-1 BW. The efficacy of DLBS2411 was measured through histopathology examination and ulceration observation. Hematological parameters were also evaluated before and after treatments to indicate the safety profile of DLBS2411. The untreated animals developed more serious injuries (i.e., bigger and more severe ulcers) than the positive control groups and DLBS2411 treatment groups. DLBS2411 treatment with doses of 25 and 50 mg kg-1 and sucralfate 100 mg kg-1 were effective to heal the ulcer as shown by reduction of ulcer size (up to 54.8, 36.53 and 14.85%, respectively) compared to the untreated animals. DLBS2411 was as effective as omeprazole 2 mg kg-1 and sucralfate 100 mg kg-1 in alleviating ulcer severity as examined in histopathology result. There were no significant differences in hematological values. DLBS2411 at doses of 25 and 50 mg kg-1 demonstrated healing activity on acetic acid-induced gastric ulcer, with a similar effect to that of omeprazole at dose of 2 mg kg-1 or sucralfate at dose of 100 mg kg-1. No adverse reaction was seen in all treatment groups, suggesting that DLBS2411 has a good safety profile in animal.
Highlights
Peptic ulcers are injuries in the mucosal areas immersed in gastric acid and pepsin, wherein normally the areas is covered with mucin secreted from mucus cells
A pilot study was performed prior to the full study of DLBS2411 on acetic acid-induced ulceration. The purpose of this pilot study was to determine whether acetic acid (80% v/v, 500 μL) could induce gastric ulcer on the mucous layer
It was apparent that edema and hemorrhagia with a lot of neutrophils infiltration were found in all groups of the ulcer producing study (Fig. 2B)
Summary
Peptic ulcers are injuries in the mucosal areas immersed in gastric acid and pepsin, wherein normally the areas is covered with mucin secreted from mucus cells. Ulceration results from imbalance between gastroprotective activity and aggressive factors such as acidpepsin secretion, mucosal barrier, mucus secretion, blood flow, cellular regeneration, prostaglandins and epidermal growth factors (Bae et al, 2011; De Barros et al, 2008). It is one of the most common gastrointestinal disorders in clinical practice which is generally treated with modern medicines such as sucralfate and omeprazole. We have conducted many studies on the potential use of herbal extracts for treatment of different kinds of diseases, especially on Cinnamomum burmannii extract for diabetes treatment. Combined with Lagerstroemia speciosa, C. burmannii has been found to induce insulin sensitivity in vitro as well as in patients in clinical studies (Nailufar and Tjandrawinata, 2011; Sitepu et al, 2016; Manaf et al, 2016; Kartolo et al, 2016; Tjandrawinata et al, 2013; Tandrasasmita et al, 2011; Tandrasasmita et al, 2014; Tjandrawinata et al, 2011)
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