The evaluation of potential toxic metal levels of various drugs used in children

Abstract

Aims: Medicines have been widely used in recent years to support the immune system. Exposure to toxic metals can occur at different stages, such as raw material procurement, production, and packaging of drugs designed to support the immune system. This exposure can lead to serious health problems. In this study, the aim was to determine the levels of toxic metals in drugs used to support the immune system in children. Methods: Ten drug samples, available in pharmacies and intended for strengthening the immune system in children, were collected. Preliminary processes were conducted for the ICP-MS analysis of these collected drugs. Following the initial preparation, levels of Arsenic (As), Copper (Cu), Zinc (Zn), Manganese (Mn), Selenium (Se), Chromium (Cr), Mercury (Hg), Lead (Pb), Cadmium (Cd), Tin (Sn), Cobalt (Co), Aluminum (Al), Molybdenum (Mo), Antimony (Sb), Nickel (Ni) were determined using an ICP-MS device. Results: In our study, we evaluated the levels of toxic metals in drugs used to support the immune system. The average levels of Cr, Zn, As, Se, Cd, and Sn in the samples were found to exceed the limits set by international organizations. However, the average levels of Al, Cu, and Hg were very close to these limit levels. On the other hand, the levels of Mo, Sb, and Pb in the analyzed products were well below the established limits. Conclusion: The levels of toxic metals in immune-supporting drugs can lead to toxicity when the results of the study are evaluated. To inform consumers and safeguard their health, it would be appropriate for manufacturers to include information about the daily intake limits set by international organizations for toxic metals and trace elements. Conducting toxicological tests, especially during these inspections, will greatly contribute to protecting the health of children and fostering the development of healthy generations.