Abstract
The association between elevated values of reactive oxygen species and a decreased antioxidant capacity defines oxidative stress. Oxidative stress involvement is blamed in many diseases, including obesity. We evaluated oxidative stress levels by FORT (Free Oxygen Radical Testing � reactive oxygen species levels) and FORD (Free Oxygen Radical Defence � antioxidant capacity value) assays in obese subjects vs. controls. FORT values were high and FORD values were low in obese patients vs. controls, notably in obese subjects with comorbidities (diabetes, hypertension, dyslipidaemia, coronary heart disease, anaemia, hepatic steatosis). We found positive correlations between FORT values and total cholesterol, uric acid, triglycerides, LDL, body mass index, HDL/total cholesterol ratio, and negative correlations between FORT and age, HDL. FORD levels correlated oppositely to FORT. Our results suggest that obesity and oxidative stress are linked.
Highlights
The association between elevated values of reactive oxygen species and a decreased antioxidant capacity defines oxidative stress
FORT values were increased in obese patients vs. controls (3.19 ± 0.40 mmol/L vs. 2.16 ± 0.38 mmol/L; pvalue
FORD values were increased in controls vs. obese patients (1.41 ± 0.44 mmol/L vs. 0.66 ± 0.16 mmol/ L; p-value
Summary
The association between elevated values of reactive oxygen species and a decreased antioxidant capacity defines oxidative stress. We evaluated oxidative stress levels by FORT (Free Oxygen Radical Testing – reactive oxygen species levels) and FORD (Free Oxygen Radical Defence – antioxidant capacity value) assays in obese subjects vs controls. Recent studies have revealed that obesity-related risk factors depend not on the excess body weight, but rather on the regional distribution of the adipose tissue. Adipokines generate reactive oxygen species (ROS) or reduce the antioxidant capacity, causing an increase in oxidative stress levels. An excessive amount of adipose tissue acts as a source of pro-inflammatory cytokines (TNF-α, IL-1 or IL-6), explaining why obesity, via low-grade chronic inflammation, leads to an increase in ROS levels and induces oxidative stress. We aimed to evaluate oxidative stress levels in obese patients with/without comorbidities vs. healthy controls
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
