Abstract
Iran, as a developing country, is experiencing high burdens of Helicobacter pylori (Hp)-associated non-communicable diseases. Hp stool antigen test (HpSA) is widely used as an inexpensive and feasible noninvasive method to diagnose Hp infection, instead of invasive approaches. The current study aimed at evaluating the diagnostic and predictive values of HpSA test for Hp infection in Iranian patients with dyspepsia. The current cross sectional study was performed on 100 patients with dyspepsia. Gastric mucosal specimens were taken, processed, and examined according to the standard protocols. Simultaneously, stool samples were obtained and sent to laboratory for further analyses. Hp stool antigen titers were assessed using enzyme-linked immunosorbent assay (ELISA) technique. Stool antigen titers were not associated with gender (P-value=0.284), but correlated to age (r=0.213, P-value=0.034). Considering 0.385 as a cutoff point, the HpSA test had 80.4% sensitivity and 85.7% specificity. Based on cost-effectiveness of HpSA test, the current study findings corroborated the use of HpSA test to detect and follow-up patients with Hp infection, as an alternative method to detect Hp rather than invasive procedures.
Highlights
Helicobacter pylori (Hp) infection is a wellknown step in gastric cancer susceptibility and other chronic gastric diseases in adults and children [1,2,3]
Based on cost-effectiveness of Hp stool antigen (HpSA) test, the current study findings corroborated the use of HpSA test to detect and follow-up patients with Hp infection, as an alternative method to detect Hp rather than invasive procedures
Materials and Methods Subjects The current cross sectional study was performed on 100 patients with dyspepsia within the age range of 20 to 70 years referred to Imam Reza Specialized Polyclinic affiliated to Arak University of Medical Sciences, Arak, Iran, from March to October 2015
Summary
Helicobacter pylori (Hp) infection is a wellknown step in gastric cancer susceptibility and other chronic gastric diseases in adults and children [1,2,3]. Prevalence of Hp infection varies by geographical regions, genetic background, and socioeconomic status [4,5,6]. Hp can be detected either invasively or non-invasively. Invasive methods, such as histopathology-based, culture, or rapid urease test (RUT), need gastric mucosa specimens obtained through endoscopy. Invasive methods are commonly used as gold standards, studies demand less invasive or noninvasive methods such as urea breath test (UBT) and Hp stool antigen (HpSA) test [8,9,10]
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