Abstract
Resuscitative hypothermia after cardiac arrest has been shown to improve neurological outcome and has been added to the recommendations for the treatment of cardiac arrest patients of the Task Force of the International Liaison Committee on Resuscitation [1-3]. However, there is clearly a need for further investigations. A population-based international database, the European Resuscitation Council (ERC) Hypothermia After Cardiac Arrest Registry (HACA-R), is on its way to provide sufficient data to answer relevant study questions (see http://www.erchacar.org, http://www.erc.edu). It was established in 2002 under the lead of the ERC. The goals of the HACA-R are: to document information of all patients with cardiac arrest admitted to one of the participating centres; to set up relevant study protocols in close collaboration with the clinicians of the ERC to further improve guidelines on application of mild therapeutic hypothermia; and to formulate hypothesis on underlying causes of the benefits of mild therapeutic hypothermia on neurological outcome of cardiac arrest patients.
Highlights
Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide
This study shows that the inhibition of the intramyocardial expression of tumour necrosis factor (TNF)-α and of its secondary mediator COX-2 related to moderate hypothermia during cardiopulmonary bypass (CPB) is associated with the inhibition of p38 mitogen-activated protein kinase (MAPK)–acute pancreatitis (AP)-1, but not of the NF-κB pathway
Nominal values of inducible nitric oxide synthase (iNOS) detected by immunoassay were based upon calibration with commercial murine iNOS standards
Summary
Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide. Methods Eighty-one consecutive patients (age 63 ± 16 years, male n = 51, SAPS 2 score 49 ± 11, mechanical ventilation n = 50, vasopressors n = 56, renal failure n = 19, postoperative n = 23) admitted to the ICU during a 3-month period were evaluated. Probiotics administration was suggested to reduce the incidence of infections and the overall morbidity and mortality in surgical patients The aim of this prospective randomized clinical trial was to assess the effects of a combination formula of probiotics and prebiotics (Synbiotic 2000Forte; Medifarm, Sweden) versus prebiotics only (fiber) in critically ill, long-term mechanically ventilated trauma patients. This study examines the acute patient outcomes associated with the evolution of early total care to damage control orthopaedics for multiply injured patients with femoral shaft fractures
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