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Abstract
In Romania, data on patch testing are lacking and the significance and applicability of the European baseline series (EBS) needs to be evaluated. The aim of the study was to examine the prevalence of contact allergy to the EBS and to determine the most common post-test sensitization occurred in the population of patients with suspected allergic contact dermatitis in Romania. Demographic data were collected from 252 patients with suspected allergic contact dermatitis. Pacients were patch tested with 28-allergen EBS.The positive patch test was observed in 80.16% patients. The most prevalent contact allergens were nickel sulphate (15.08%), fragrance mix I & II (13.10%) and potassium dichromate (9.52%). Differences in sensitization prevalences to some allergens of the EBS compared with other European countries were recognized. The current EBS is a suitable diagnostic tool for contact allergy in Romania.
Highlights
In Romania, data on patch testing are lacking and the significance and applicability of the European baseline series (EBS) needs to be evaluated
The prevalence of contact allergy in general population is estimated at 25 - 40 %, while the prevalence of allergic contact dermatitis over lifetime is approximately 10%
Allergic contact dermatitis is based on the pathophysiological mechanism of delayed hypersensitivity, reaction typically exemplified by allergic eczema determined by contact with poison ivy
Summary
In Romania, data on patch testing are lacking and the significance and applicability of the European baseline series (EBS) needs to be evaluated. The aim of the study was to examine the prevalence of contact allergy to the EBS and to determine the most common post-test sensitization occurred in the population of patients with suspected allergic contact dermatitis in Romania. Considered the “father” of contact dermatitis, Jozef Jadassohn (1863-1936) described this condition and released patch testing technique, a technique which is today essential diagnostic method for finding contact allergy. Diagnosis of allergic contact dermatitis involves two main features: the establishment of delayed hypersensitivity and patient exposed demonstration to some sensitization, both processes of this type of condition warranting investigation. Patients with relevant history of contact dermatitis is re-exposed to a suspected allergen to be the causative, exposure takes place under safety controlled conditions to verify the diagnostic
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