Abstract
The eukaryotic linear motif (ELM http://elm.eu.org) resource is a hub for collecting, classifying and curating information about short linear motifs (SLiMs). For >10 years, this resource has provided the scientific community with a freely accessible guide to the biology and function of linear motifs. The current version of ELM contains ∼200 different motif classes with over 2400 experimentally validated instances manually curated from >2000 scientific publications. Furthermore, detailed information about motif-mediated interactions has been annotated and made available in standard exchange formats. Where appropriate, links are provided to resources such as switches.elm.eu.org and KEGG pathways.
Highlights
In recent years, our understanding of the nature of protein–protein interactions has changed dramatically
Links are provided to resources such as switches.elm.eu.org and KEGG pathways
Short linear motifs (SLiMs), a class of compact, degenerate and convergently evolvable interaction modules, are the predominant functional modules found in intrinsically disordered regions [5,6,7]
Summary
Our understanding of the nature of protein–protein interactions has changed dramatically. Short linear motifs (SLiMs), a class of compact, degenerate and convergently evolvable interaction modules, are the predominant functional modules found in intrinsically disordered regions [5,6,7]. As a result of the limited number of binding determinants in a short linear motif, novel SLiMs can readily evolve de novo, adding functionality to a protein.
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