Abstract

To better understand the process of the cellular transformation and conversion of proto-oncogenes to the transforming retroviral oncogenes, our laboratory has pursued the study of the normal cellular genes comparing these to the homologous viral oncogemes. We have focused on the ets gene family which are related to sequences originally identified as a second cellular derived genes transduced by the avian leukemia virus, E26 (Watson et al. 1985). In mammals there are three ets genes located on two different chromosomes, termed ets-1, ets-2 and erg. The ETS-1 gene most related to the cellular ets captured by the virus (v-ets) is located in chromosome 11; the ETS-2 and ERG genes are located on chromosome 21. In higher mammals as well as humans these ets genes, are dispersed in separate chromosomes; but retain their homologous syntenic groups with respect to other genetic markers (Watson et. al. 1986). The ets genes are transcriptionally active, their gene products are homologous to one another and they are differentially regulated. Figure 1 presents a diagramatic comparison of the amino acid sequences of a wide variety of species ranging from Drosophila to humans.

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