Abstract
(B) URIC-ACID METABOLISM IN GOUT AND THE THEORIES OF GOUT PRODUCTION. There is undoubtedly marked disturbance of nitrogenous metabolism in gout. Since the adoption of the classification of purins into the endogenous and varieties, too little time has elapsed and too few researches have been published to draw absolute conclusions as to how the metabolism of each is affected in this disease. The studies of Reach, Kaufmann, Vogt and Chalmers Watson show that in gout the exogenous nuclein is more slowly excreted than in health, and that in some cases there is a distinct retention. Vogt compared the results of rich purin-holding food on a gouty patient and a healthy individual at the same time. The gouty patient showed retention and delayed excretion of the purin bodies. It can be safely admitted, therefore, that exogenous purins lead to the excess of nuclein derivatives in the blood stream. It
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