The etiology and clinical features of 86 cases of drug-induced liver injury in old people

Abstract

Objeetive To enhance the understanding of drug-induced liver injury by investigating the causes and clinical features of drug-induced liver injury cases in old people. Methods Eight- six drug-induced liver injury cases in old people admitted to our hospital from 2004-2010 were retrospectively analyzed and evaluated by using Maria＇s diagnostic scale. Results The four predominant etiologi cal drugs were antibiotics （ 19 cases, 22% ）, antitumor drugs （ 17 cases, 19.8% ）, traditional Chinese herbs （ 16 cases, 18.6% ） and cardiovascular drugs （ 14 cases, 16.3% ）, followed by neurologists medicines （ 4% ） and antipyretic analgesics （ 4% ）. Other drugs included glucose-lowing drugs, hyper- thyroidism drugs and immunosuppressive agents, each of them accounted for 2.3% of the all cases. 1.2% cases attributed to male hormone drugs and the causative drugs could not be clarified in 8 cases （ 5.8% ）. For clinical classification, 49 cases （ 57% ） were hepatocellular type, 25 cases （ 29% ） were cholestasis type, and 12 cases （ 14% ） were mixed type. Conclusions Antibiotics, antitumor drugs, traditional Chinese herbs and cardiovascular drugs are the common drugs cause drug-induced liver injury among old people, doctors should be discreet and closely monitor the liver function when using these drugs. Key words: Old people; Liver injury; Drug-induced ; Etiology