Abstract
Objective: The present research study was conducted to investigate in vitro anti-diabetic potentials of ethanol extract of leaves of Muntingia calabura for α-glucosidase and α-amylase inhibitory activities.
 Materials & Methods: The leaves of Muntingia calabura were collected and authenticated. dried and powdered. The powdered drug was defatted using petroleum ether and extracted with ethanol. The ethanol extract of Muntingia calabura was subjected to preliminary phytochemical investigation. The in vitro α-glucosidase inhibitory and α-amylase inhibitory properties were determined for the ethanol extract and concentrations of extract required to inhibit absorbance (IC50 values) EEMC were determined.
 Results: Significant IC50 values were found in both tests that assessed the inhibitory activity of α-glucosidase and α-amylase, demonstrating the capacity of the ethanol extract of Muntingia calabura to block carbohydrate digesting enzymes and prevent postprandial blood glucose.
 Conclusion: The results of the presents investigation recommends that ethanol extract of Muntingia calabura possess significant α-glucosidase and α-amylase inhibitory activity.
 Keywords: Antidiabetic activity, Muntingia calabura, α-glucosidase and α-amylase and IC50values.
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