Abstract
The percentage of intestinal alkaline phosphatase in sera with normal and elevated total alkaline phosphatase activities due to various diseases was estimated by its sensitivity to inhibition by l-phenylalanine. The results obtained with two different substrates, p-nitrophenyl phosphate and phenyl phosphate, were compared. On average,only 14% of the total alkaline phosphatase activity in normal serum was of intestinal origin by this criterion. This percentage was not significantly different in patients with a raised serum phosphatase level. A comparative study of the action of d- and l-phenylalanine on alkaline phosphatases purified from small intestine and liver was made. Some apparent discrepancies between earlier reports on the proportion of intestinal alkaline phosphatase in human serum are discussed.
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