Abstract
Objective Idiopathic scoliosis is a structural, lateral, rotated curvature of the spine. Scoliosis may worsen progressively, in some cases leading to back pain, body image concerns, and cardiopulmonary compromise. To date, a variety of pathogenic factors have been proposed as a cause of idiopathic scoliosis. However, the pathogenesis of idiopathic scoliosis remains unclear, and a consistent and relevant animal model has not yet been established. We recently reported that the anteroposterior chest dimension in patients with thoracic scoliosis was significantly smaller than that in normal subjects and that there was a correlation between the anteroposterior chest dimension and the severity of the thoracic curvature. These findings led us to hypothesize that rib cage deformities were associated with the etiology of the thoracic scoliosis. The goal of this study was to clarify whether a shallow chest depth is a causative factor or a consequence of structural scoliosis, and also to establish a nonsurgical mouse model of progressive scoliosis.
Highlights
In some cases leading to back pain, body image concerns, and cardiopulmonary compromise
A variety of pathogenic factors have been proposed as a cause of idiopathic scoliosis
We recently reported that the anteroposterior chest dimension in patients with thoracic scoliosis was significantly smaller than that in normal subjects and that there was a correlation between the anteroposterior chest dimension and the severity of the thoracic curvature
Summary
Kensuke Kubota1,2*, Seiji Okada[1,3], Toshio Doi[1,4], Kazu Kobayakawa[1], Yoshihiro Matsumoto[1], Katsumi Harimaya[1], Takeshi Maeda[5], Yukihide Iwamoto[1]. From The 10th Meeting of the International Research Society of Spinal Deformities (IRSSD 2014 Sapporo) Sapporo, Japan. From The 10th Meeting of the International Research Society of Spinal Deformities (IRSSD 2014 Sapporo) Sapporo, Japan. 29 June - 2 July 2014
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
