Abstract
BackgroundThe ability of mosquitoes of the genus Aedes and its allies, such as Stegomyia, to transmit diseases such as dengue and yellow fever, makes them important in public health. This study aims to evaluate the use of the essential oil of Brazilian pepper in biological control of by assessing and quantifying the larvicidal effect against S. aegypti, the only available access to dengue control, and test its risk of genotoxicity with Salmonella typhimurium as an indicator of safety for its environmental use.ResultsThe density of the oil was 0.8622 g mL-1. Gas chromatography coupled with mass spectrometry revealed six major constituents: δ-3-carene (55.43%), α-pinene (16.25%), sylvestrene (10.67%), germacrene D (2.17), β-myrcene (1.99%), and isoterpinolene (1.4%). The minimum inhibitory dose to larvae development was 862.20 μg mL-1. The median lethal dose (LD50) of the essential oil for larvae was between the concentrations of 172.44-344.88 μg mL-1. There was no mutagenic risk for the essential oil, since there were no biochemical or morphological changes in S. typhimurium after exposure to the essential oil.ConclusionsThe minimum inhibitory essential oil concentration and the median lethal dose pointed to the value of the use of water dispersions of Brazilian pepper essential oil as an environmental safe natural larvicidal for S. aegypti.
Highlights
Dengue was eradicated in Brazil in 1955, but outbreaks of this tropical disease have been occurring since the 70 s [1]
The mosquito that acts as the dengue fever vector is S. aegypti (Linnaeus, 1762), a new combination for Aedes aegypti [5], and it has morphological characteristics that make its identification easy, such as brown wings and a silver-white strip on each side of its thorax [6,7]
Since there is no information about the use of the essential oil of S. therebintifolia in larval control of S. aegypti, this study aims to investigate biological control of this mosquito by the use of essential oil of Brazilian pepper, as well as to assess and quantify the larvicidal effect, and to evaluate its risk of genotoxicity in Salmonella typhimurium ATCC 14028, as an indicator of safety for environmental use
Summary
Dengue was eradicated in Brazil in 1955, but outbreaks of this tropical disease have been occurring since the 70 s [1]. The mosquito that acts as the dengue fever vector is S. aegypti (Linnaeus, 1762), a new combination for Aedes aegypti [5], and it has morphological characteristics that make its identification easy, such as brown wings and a silver-white strip on each side of its thorax [6,7]. They are long distance flyers and are attracted by hosts and by the interaction of physical, chemical, biological and sensorial factors, such as vision and olfaction. There was no mutagenic risk for the essential oil, since there were no biochemical or morphological changes in S. typhimurium after exposure to the essential oil
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