Abstract
The basal concentration of lead in milk of lactating rabbits is approximately 65% that of blood. After the intravenous injection of lead acetate, the lead concentration in blood peaked at 1 hour and thereafter declined rapidly, reaching a plateau within 5 days. In contrast, the lead concentration in milk continuously increased with time and by 7.5 days (maximum) exceeded that of blood 8-fold. The possibility that passage of Pb ++, like Ca ++, Sr ++ and other ions from blood to milk occurs against a concentration gradient is suggested. The consequences of this observation on subclinical lead poisoning in neonates is discussed.
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