Abstract
Mayaro virus (MAYV) is an arbovirus that is endemic to tropical forests in Central and South America, particularly within the Amazon basin. In recent years, concern has increased regarding MAYV's ability to invade urban areas and cause epidemics across the region. We conducted a systematic literature review to characterise the evolutionary history of MAYV, its transmission potential, and exposure patterns to the virus. We analysed data from the literature on MAYV infection to produce estimates of key epidemiological parameters, including the generation time and the basic reproduction number, R0. We also estimated the force-of-infection (FOI) in epidemic and endemic settings. Seventy-six publications met our inclusion criteria. Evidence of MAYV infection in humans, animals, or vectors was reported in 14 Latin American countries. Nine countries reported evidence of acute infection in humans confirmed by viral isolation or reverse transcription-PCR (RT-PCR). We identified at least five MAYV outbreaks. Seroprevalence from population based cross-sectional studies ranged from 21% to 72%. The estimated mean generation time of MAYV was 15.2 days (95% CrI: 11.7-19.8) with a standard deviation of 6.3 days (95% CrI: 4.2-9.5). The per-capita risk of MAYV infection (FOI) ranged between 0.01 and 0.05 per year. The mean R0 estimates ranged between 2.1 and 2.9 in the Amazon basin areas and between 1.1 and 1.3 in the regions outside of the Amazon basin. Although MAYV has been identified in urban vectors, there is not yet evidence of sustained urban transmission. MAYV's enzootic cycle could become established in forested areas within cities similar to yellow fever virus.
Highlights
Mayaro virus (MAYV) is an enveloped, single-stranded RNA virus with a complex transmission cycle involving mosquitoes and animals, including non-human primates, birds, horses, rodents, and reptiles [1,2,3]
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Diseases that are transmitted by mosquitoes cause substantial deaths and disability across the world
Summary
Mayaro virus (MAYV) is an enveloped, single-stranded RNA virus with a complex transmission cycle involving mosquitoes and animals, including non-human primates, birds, horses, rodents, and reptiles [1,2,3]. MAYV belongs to the Togaviridae family and Alphavirus genus. Along with Una virus (UNAV), it is classified as a new world member of the Semliki forest antigenic complex [4]. Phylogenetic studies have identified a least three MAYV genotypes, D (widely dispersed), L (limited), and N (new) [5,6,7], with limited geographic distribution possibly linked to host range and vector habitat suitability. In 1954, MAYV was first discovered in forest workers in Mayaro County, Trinidad and Tobago [8]. The virus has caused sporadic outbreaks of febrile disease in Central and South America [5,9,10,11,12]
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