THE ENZYMOLOGICAL STUDY IN GASTRIC MUCOSA

Abstract

LDH, HBD, LAP, γ-GTP, ALP and ACP activity levels and LDH isoenzymes in gastric mucosa were studied.The materials were obtained by endoscopic biopsy from the stomach. Thirteen patients who were determined endoscopically normal, 26 patients who had gastric ulcer and 29 patients who had cancer were investigated. The results were as follows : 1. In caner tissue, the activity levels of five enzymes except HBD were higher than those of normal gastric mucosa. Some differences in the activity levels of those enzymes were observed in histologically different types.2. LDH-M subunit values (%) were relatively higher in well differentiated cancer tissue than in poorly differetiated one.3. Statistical study revealed no difference between cancer lesions and the neighbouring mucosa about LDH isoenzyme.4. Only in the upper part of the greater curvature, LDH-M subunit values showed significantly higher in cancer bearing gastric mucosa than in normal gastric mucosa.5. The older the age of patients, the less the activity levels of LDH, HBD, LAP and γ-GTP were observed. As the age progressed, the ratio of LDH-M subunits was increased, especially in the upper part of the lesser curvature.