Abstract
Abstract1. Methylenedioxyphenyl compounds (piperonyl butoxide, methylene-dioxybenzene, isosafrole) were metabolized by rat liver microsomes in the presence of oxygen and NADPH (but not NADH) to give products which exhibited an isocyanide-like absorption spectrum with reduced cytochrome P-450 of liver microsomes.2. The presence of hexobarbital inhibited the formation of the isocyanide-like spectrum, presumably by inhibiting the formation of the metabolite.3. The optical spectrum absorption characteristics of the complex of the metabolite with reduced cytochrome P-450 varied with changes in pH.4. The metabolite, or the metabolite-cytochrome P-450 complex formed, was sufficiently stable to survive the oxidation and re-reduction of the microsomal cytochrome P-450.
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