Abstract
Phosphatidylcholine (PC) is an appealing molecule for stabilizing nanoemulsions due to its natural origin. PC can be modified to improve its physicochemical features or biological activities. On the other hand, conjugated linoleic acid (CLA) is a fatty acid with proven favorable biological activities. Replacing native PC fatty acids with CLA could modify the physicochemical properties of PC as well as its biological benefits. PC was enzymatically modified in this work to replace some of its fatty acids with CLA. The results showed molar incorporation of CLA of 56.3%, with reaction yields of 71.5%. In addition, we found that the modified PC enabled the reduction of its critical micelle concentration from 1.05 mM to 0.083 mM. Finally, both phospholipids successfully formed nanoemulsions with particle sizes of ca. 57 nm; however, nanoemulsions developed with modified PC showed greater stability after 60 days, demonstrating a superior surface coverage of the modified PC to the nanoemulsion.
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