Abstract
ABSTRACTAcidic glycosaminoglycans (GAG) prepared from scar and keloid, was assayed for separation and quantitative measurement with the paper chromatographic characteristic of the unsaturated disaccharide unit after chondroitinase digestion. The following results were obtained: It was found that the total amount of GAG in scars was greatly increased, especially in earlier phases, in comparison with that of normal tissue, and it gradually decreased with time. Even in different phases of scar, a decrease of hyaluronic acid (HA) was commonly observed in contrast to an increase in sulfated GAG, i.e. dermatan sulfate (DS) in particular amoung constituents. A similar behavior of GAG to their mentioned above was observed in keloid specimens. Any striking difference of GAG constituents between the scar in the hypertrophic phase and the keloid remained indistinguishable.
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