Abstract
The entanglement between flaviviruses and ER-shaping proteins.
Highlights
The flaviviruses replicate on the endoplasmic reticulum (ER) membranes and form immature viral particles that bud into the ER lumen
While amount of vesicle membranes per vesicle packets (VPs) was not altered in dengue virus (DENV)-infected cells, their morphology became more elongated (Fig 2C), and there was an increase in immature viral particles upon RTN3.1A depletion (Fig 2C) [21]
The depletion of ATL3 reduced the titers of Zika virus (ZIKV) and DENV and had no effect on viral-RNA levels [17] [30]
Summary
The flaviviruses replicate on the ER membranes and form immature viral particles that bud into the ER lumen. This Pearl review will explore the virus-induced ER-membrane rearrangement and the relationship between ER-shaping proteins and the flavivirus life cycle. Virus-induced morphological changes to the ER membrane are brought about by active restructuring facilitated by interactions between viral proteins and host factors.
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