Abstract
For amide derivatives of 1-phenyl-1-ethylamines and for diethyl 1-(N-3,5-dimethylphenyl)amino-1-phenylmethanephosphonates with halogen substituents in the meta or para position of the benzenoid ring, increased retention and enantioselectivity are noted relative to their nonhalogenated counterparts. This is unexpected on the basis of prior observations that halogen substituents on benzenoid rings presumably undergoing face to face π-π interactions show reduced retention and enantioselectivity. These observations raise questions concerning the effect of polarizable electron-withdrawing substituents on the π-basicity of benzenoid systems.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
