The energy dependent redox responses of heme and copper in cytochrome oxidase in rat brain in situ.

Abstract

With the in vitro calibration of isolated mitochondria, it has been shown that the redox state of heme a+a3 in cytochrome oxidase depends on both mitochondrial energy state and respiratory rate, but that of copper does not (1,2, 3). This finding, however, has not been confirmed in vivo living tissues, since hemoglobin absorption masks the redox change of heme a+a3 in the visible region.KeywordsCytochrome OxidaseCerebral TissueRedox BehaviorRapid PhaseRedox LevelThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.