The endothelial dysfunction in patients with arterial hypertension after old hemorrhagic stroke.

Abstract

The higher risk of development of cerebral complications in patients with arterial hypertension is related to formation of dysfunction of endothelium preventing appropriate regulation of cerebral bloodstream. The decreasing of athrombogenic characteristics of vessel wall can results in increased adhesion of thrombocytes on endothelium of wall of vessels, activation of hemostasis system and thrombosis. The purpose of the study is to establish the level of markers of dysfunction of endothelium-von Willebrand factor and tissue activator plasminogen in patients with arterial hypertension in dynamics after old hemorrhagic stroke. The sampling of examined patients consisted of 82 persons (main group) with arterial hypertension in various periods after old hemorrhagic stroke. To evaluate condition of endothelium activity of von Willebrand factor was detected using the technique of ristocetin-cofactor activity applying the reagents' set by Dade Behring (Germany). Also, the level of antigen and indicator of activity of tissue activator plasminogen was detected using immune enzyme technique ELISA Actibind t-PA applying reagents' set Technoclone (Austria). The statistical data processing was implemented by integrated software Statistica 8 for Windows (StatSoft). In patients with arterial hypertension independently of period of hemorrhagic stroke an endothelial dysfunction is detected presented by decreasing of level of tissue plasminogen activator and increasing of its activity. The increasing of activity of von Willebrand factor was established only in patients at early rehabilitation period of hemorrhagic stroke that indicates the stablecharacter of endothelial dysfunction in the given category of patients. The established disorders related to pathology of vessel wall can be characterized as prothrombotic that is a prognostically unfavorable factor and substantiates necessity of medicinal correction of detected disorders.