Abstract

The principal function of plasma lipoproteins is to transport water-insoluble lipid from its site of synthesis and absorption to peripheral cells. In modern industrialized societies where overconsumption of animal fat is common, plasma lipoproteins are dramatically increased leading to an increased incidence of atherosclerotic cardiovascular disease. In an attempt to design methods to prevent the occurrence of atherosclerosis, a great amount of effort has been applied to understanding the molecular mechanisms through which plasma lipoproteins are assembled and secreted. The major focus of this chapter is to describe these mechanisms, many of which are distinct from the paradigms describing the assembly, intracellular targeting, and metabolism of other lipid-protein macromolecular aggregates (e.g., membranes, vesicles, and viruses). These distinctions provide new insights into a regulatory secretion mechanism intimately linked to the physicochemical forces governing the translocation and integration of proteins in the endoplasmic reticulum (ER). Since very-low-density lipoprotein (VLDL) is the principal, if not sole, precursor of the other plasma lipoproteins, we will focus our attention on the molecular interactions involved in its assembly and secretion.KeywordsHepG2 CellMicrosomal Triglyceride Transfer ProteinIntracellular DegradationMolecular Weight FormVLDL ParticleThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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