Abstract

The endogenous estrone (E 1) and estradiol (E 2) levels (pg/g tissue) were measured in 54 postmenopausal, atrophic endometria and compared with the E 1 and E 2 levels in plasma (pg/ml). The results from the tissue levels of both steroids showed large variations and there was no significant correlation with their plasma levels. The mean E 2 concentration in tissue was 420 pg/g, 50 times higher than in plasma and the E 1 concentration of 270 pg/g was 9 times higher. The E 2/E 1 ratio in tissue of 1.6, was higher than the corresponding E 2/E 1 ratio in plasma, being 0.3. We conclude that normal postmenopausal atrophic endometria contain relatively high concentrations of estradiol and somewhat lower estrone levels. These tissue levels do not lead to histological effects.

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