The empirical pharmacodynamics study of compound orange peel bamboo shavings formula capsules in chemical constipation

Abstract

Objective To explore the effect of compound orange peel bamboo shavings formula capsules on constipation by examining on chemical constipation mice. Methods Constipation was induced by oral administration of diphenoxylate and ondansetron. Mice were fed with compound orange peel bamboo shavings formula capsule at the doses of 3.2, 1.6 and 0.8 g/kg, respectively. Results The middle dose and high dose of compound orange peel bamboo shavings formula capsule shortened the start time of defecation, and increased fecal pellets number and wet weight in the diphenoxylate-induced constipated mice or the ondansetron-induced constipated mice (P< 0.05). Conclusion Compound orange peel bamboo shavings formula capsule produces a laxative activity against diphenoxylate-induced constipated mice or ondansetron-induced constipated mice. Key words: Compound orange peel bamboo shavings formula capsules; Constipation; Diphenoxylate; Ondansetron