Abstract
Introduction: Hospital infections are serious medical problem, causing deterioration in patients’ outcome, prolonged hospital stay and increase costs of hospitalization. Rapid administration of wide spectrum antimicrobial agents is a well known way to increase patient survival rate. Aim: To analyze the efficacy of initial empiric antimicrobial treatment in a large academic hospital. Methods: In this retrospective cohort study, the initial choice of empiric therapy was compared with the results of the microbiological investigation and the susceptibility/resistance of isolated pathogens. Results: Between February 1, 2018 and February 1, 2020, a total number of 267 samples were analyzed. Amongst all 267 samples 163 (61%) were positive and 104 (39%) were negative. In those 163 samples 247 pathogens were isolated. In empirical therapy the most frequently administered antibiotic was meropenem (55/267, 20.6%), vancomycin (16/267, 6%), meropenem with vancomycin (14/267, 5.2%), ceftazidime (11/267, 4.1%), and imipenem/cilastatin (5/267, 1.9%). The total number of samples where the empiric therapy corresponded with the results of microbiological tests was 166. There were forty-seven (28.3%) Gram positive bacteria, including 11 MRSA and 1 VRE, and 119 (71.7%) Gram negative pathogens, including 35 K. pneumoniae ESBL+, 12 A. baumannii, and 2 E. coli ESBL+. In 81 cases, the isolated pathogens were resistant to empirically administered drugs. The empiric antimicrobial therapy complied with the results of microbiological analyses in 67.2% (166/247) of cases. Conclusion: In our center, meropenem and vancomycin seem to be a good choice in empiric therapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Polish Journal of Aviation Medicine, Bioengineering and Psychology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
