Abstract
Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs, and the accessibility of various RNA-binding proteins to the mRNAs. Recent advances in high-throughput RNA-sequencing techniques have resulted in the elucidation of the important roles played by mRNA modifications and mRNA nucleotide sequences in regulating mRNA stability. To date, hundreds of different RNA modifications have been characterized. Among them, several RNA modifications, including N6-methyladenosine (m6A), N6,2′-O-dimethyladenosine (m6Am), 8-oxo-7,8-dihydroguanosine (8-oxoG), pseudouridine (Ψ), 5-methylcytidine (m5C), and N4-acetylcytidine (ac4C), have been shown to regulate mRNA stability, consequently affecting diverse cellular and biological processes. In this review, we discuss our current understanding of the molecular mechanisms underlying the regulation of mammalian mRNA stability by various RNA modifications.
Highlights
Many recent studies have demonstrated that RNA undergoes various modifications in a manner similar to DNA
Recent reports have posited that the regulation of mRNA stability through RNA modification is a crucial step for the tight regulation of gene expression[1,2,3,4,5,6,7,13]
In this review, we aim to highlight recent progress made in our understanding of the molecular mechanisms underlying the regulation of mRNA stability through various mRNA modifications, including N6-methyladenosine (m6A), N6,2′-O-dimethyladenosine (m6Am), 8-oxo-7,8-dihydroguanosine (8-oxoG)
Summary
Many recent studies have demonstrated that RNA undergoes various modifications in a manner similar to DNA. These RNA modifications play a role in many cellular and biological processes, thereby opening up an emerging research field known as epitranscriptomics[1,2,3,4,5,6,7]. Recent reports have posited that the regulation of mRNA stability through RNA modification is a crucial step for the tight regulation of gene expression[1,2,3,4,5,6,7,13]. In this review, we aim to highlight recent progress made in our understanding of the molecular mechanisms underlying the regulation of mRNA stability through various mRNA modifications, including N6-methyladenosine (m6A), N6,2′-O-dimethyladenosine (m6Am), 8-oxo-7,8-dihydroguanosine (8-oxoG), Official journal of the Korean Society for Biochemistry and Molecular Biology
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